If given as a continuous IV infusion, only heparin given in the preceding 2 to 4 hours should be considered when administering protamine (ACCP Park 2021). IV: Note: Since heparin disappears rapidly from the circulation, the dose of protamine is adjusted based upon the time since heparin administration (see table). Heparin (intravenous) neutralization/reversal: Limited data available: Vitamin K: It plays a key role in blood coagulation but it is not enough to combat any ill effects caused by an excessive dosage of heparin.Note: 1 mg of protamine sulfate neutralizes ~100 units of heparin or 1 mg of enoxaparin (ACCP ).Aminocaproic Acid: It is an antifibrinolytic agent used to cause postoperative clotting. It is not an antidote for heparin.Potassium Chloride: It is a medication used to treat low levels of blood potassium.It is not an antidote for heparin.In case of heparin overdose, it can be used to combat and reverse its ill effects.

NOTE -> Protamine sulphate is an antidote for Heparin. In case of a drug overdose, an antidote is and is essential to prevent any severe drug effect.

Heparin is an anticoagulant and is used on many occasions in medical practice.

IV route of drug administration ensures maximum bioavailability of the drug as there is no first pass metabolism involved in this mode of drug administration.

Intravenous route: It is a parenteral route of drug administration wherein the drug is directly injected into the vein of the patient.

Antidote for heparin overdose